Table 3.

Exosomal circRNAs in clinical applications

CircRNA	Disease type	Specimen source	Specimen type	Expression	AUC	Citation
hsacirc_020135	PTC	PTC/benign thyroid goiter	Serum	Downregulated	–	[105]
hsa circ 0002577	Endometrial cancer	Endometrial cancer/healthy	Serum	Upregulated	–	[106]
hsa_circ_0065149	GC	GC/healthy/gastritis	Plasma	Downregulated	0.769	[100]
three-circRNA signature	HCC	HCC/healthy	Serum	Upregulated	0.89	[99]
hsa-circRNA-0088088	Breast cancer	Breast cancer/healthy	Serum	Upregulated	–	[102]
hsa-circRNA-00005795	Breast cancer	Breast cancer/healthy	Serum	Downregulated	–	[102]
CircRNA-002178	LUAD	LUAD/healthy	Serum	Upregulated	0.9956	[104]
hsa_circRNA_0056616	LUAD	With lymph node metastasis/without	Plasma	Upregulated	0.812	[103]
Circ-0051443	HCC	HCC/healthy	Plasma	Downregulated	0.8089	[80]
circ-0004771	CRC	CRC/healthy	Serum	Upregulated	0.88	[114]
hsa_circ_0087862	Immune-mediated demyelinating	Immune-mediated demyelinating/healthy	Cerebrospinal fluid	Upregulated	1	[115]
circ-KIAA1244	GC	GC/healthy	Plasma	Downregulated	0.7481	[116]

PTC papillary thyroid carcinoma, GC gastric cancer, HCC hepatocellular carcinoma, LUAD lung adenocarcinoma