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. 2021 Mar 11;22(3):297–313. doi: 10.1007/s10522-021-09915-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — p16^ink4a and SIRT1 protein level after treatment with bCUR, RSV and BCP and their combination in RS- and IS-HUVECs. a and c p16^ink4a protein level and densitometric analysis; b and d SIRT1 protein level and densitometric analysis. Data are reported as fold change vs untreated senescent HUVECs. All data were normalized using α-tubulin as internal control. Bands were quantified by ImageJ; histograms represent the mean of the protein expression detected in three different experiments ± SD. Paired t test *p < 0.05 versus RS- and IS-HUVECs; **p < 0.01 versus RS- and IS-HUVECs. bCUR, bioCurcumin; RSV, resveratrol; BCP, β‐caryophyllene; RS, replicative senescence; IS, induced senescence. RS-HUVECs data are depicted in the left panel (solid-coloured histograms); IS-HUVECs data are reported in the right panel (striped histograms)