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. 2021 Apr 19;35(3):325–336. doi: 10.1007/s40259-021-00482-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License, which permits any non-commercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc/4.0/.

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Fig. 2 — Mean changes in a CDAI score from baseline at week 4, 8, and 12 and b PRO2 score from baseline at week 4, 8, and 12. Error bars show standard error of the mean. All 18 enrolled patients were included in the analysis (intention-to-treat population; last observation carried forward analysis). CDAI Crohn’s Disease Activity Index, PRO2 two-item patient-reported outcomes