Table 1.
Patient characteristics and outcome data
| Bacteria (n) |
S. lugdunensis n = 30 |
CoNS n = 262 |
P value CoNS vs S. lugdunensis |
S. aureus n = 1892 |
P value S. aureus vs S. lugdunensis |
|---|---|---|---|---|---|
| Background data | |||||
| Age (years); median (IQR) | 73 (65–84) | 72 (61–80) | 66 (45–79) | p = 0.01 | |
| Gender-female | 11 (37%) | 86 (33%) | 725 (38%) | ||
| Diabetes | 9 (30%) | 58 (22%) | 349 (18%) | ||
| Cancer last 5 years | 6 (20%) | 46 (18%) | 173 (9%) | p = 0.042 | |
| IV drug users | 0 (0%) | 9 (3%) | 448 (24%) | p = 0.002 | |
| Prosthetic valve | 8 (27%) | 115 (44%) | 255 (14%) | p = 0.037 | |
| Pacemaker/ICD | 1 (3%) | 74 (28%) | p = 0.031 | 324 (17%) | p = 0.046 |
| Native valve disease | 5 (17%) | 55 (21%) | 222 (12%) | ||
| Treatment delay, days median (IQR) | 9 (4-15) | 10 (3–26) | 5 (2-9) | p < 0.001 | |
| Dukes criteria | |||||
| Definite | 27 (90%) | 194 (74%) | 1544 (82%) | ||
| Possible | 3 (10%) | 67 (26%) | 338 (18%) | ||
| Localisation | |||||
| Aortic | 18 (60%) | 121 (46%) | 577 (31%) | p = 0.001 | |
| Mitral | 10 (33%) | 76 (29%) | 596 (32%) | ||
| Tricuspid | 1 (3%) | 22 (8%) | 441 (23%) | p = 0.01 | |
| Type of infection | |||||
| Prosthetic IE | 6(20%) | 110 (42%) | p = 0.02 | 245 (13%) | |
| Pacemaker/ ICD IE | 1(3%) | 48 (18%) | p = 0.01 | 179 (9%) | |
| Native valve IE | 21 (70%) | 90 (35%) | p = 0.0001 | 1103 (58%) | |
| Community acquired | 25 (83%) | 179 (68%) | 1543 (82%) | ||
| Outcome | |||||
| Antibiotic treatment, median days (IQR) | 31 (18–37) | 35 (28–42) | p = 0.046 | 30 (28-40) | |
| Embolisation | 2 (7%) | 62 (24%) | p = 0.033 | 907 (48%) | p < 0.001 |
| Surgical intervention | 7 (23%) | 111 (42%) | p = 0.044 | 455 (24%) | |
| Day of surgery, median (IQR) |
5 (1–9) |
12 (5-20) |
12 (7-23) |
||
|
Mortality at 30 days In-hospital mortality |
6 (20%)* 7 (23%) |
17(7%) 49 (19%) |
166 (9%) 268 (14%) |
||
| Day of death in hospital, Median (IQR) | 9 (8–23) | 36 (28–47) | p = 0.007 | 25 (14-39) | p = 0.016 |
Data are presented as number and (%) unless otherwise stated. Survival data calculated with Kaplan-Meier survival curve and log-rank test
ICD intracardiac device, IQR interquartile range
*p = 0.016