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. 2021 Mar 19;152(3):551–557. doi: 10.1007/s11060-021-03725-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Example $^{13}$ C-metabolite images of an intracranial metastasis (arrows) in a renal cell carinoma (RCC) patient. The metabolite signals are displayed as colour overlays on the corresponding greyscale T1-weighted anatomical images, and were computed by summing 12 time-points collected over a 60 s acquisition window. The treatment of this high-lactate lesion with SRS failed, with local progression prior to the 6-month followup