. Author manuscript; available in PMC: 2022 Jun 1.

Published in final edited form as: AIDS Behav. 2021 Jan 1;25(6):1699–1710. doi: 10.1007/s10461-020-03096-6

Table 3:

Difference in Symptom Burden Score from period 1 to period 3

Symptom^a	Arm	Estimate^b	SE	p-value^c	Compare 2 arms p-value^d
Muscle aches or pain	Intervention	0.36	0.10	0.001	0.940
Muscle aches or pain	Control	0.34	0.09	0.001	0.940
Overall low energy or fatigue	Intervention	0.58	0.09	<0.001	0.951
Overall low energy or fatigue	Control	0.59	0.08	<0.001	0.951
Decreased sex drive	Intervention	0.18	0.08	0.069	0.100
Decreased sex drive	Control	0.43	0.08	<0.001	0.100
Depression	Intervention	0.02	0.10	0.876	0.049
Depression	Control	0.40	0.09	<0.001	0.049
Anxiety	Intervention	0.22	0.09	0.032	0.951
Anxiety	Control	0.23	0.08	0.013	0.951
Difficulty staying asleep	Intervention	−0.08	0.09	0.480	0.094
Difficulty staying asleep	Control	0.19	0.08	0.064	0.094
Difficulty concentrating	Intervention	0.02	0.07	0.863	0.122
Difficulty concentrating	Control	0.22	0.07	0.005	0.122
Difficulty falling asleep	Intervention	−0.07	0.09	0.560	0.295
Difficulty falling asleep	Control	0.12	0.09	0.299	0.295
Unplanned changes in weight	Intervention	0.03	0.08	0.795	0.076
Unplanned changes in weight	Control	0.29	0.07	0.001	0.076
Lightheadedness or dizziness	Intervention	0.01	0.08	0.940	0.076
Lightheadedness or dizziness	Control	0.27	0.07	0.001	0.076
Thirst or dry mouth	Intervention	0.39	0.09	<0.001	0.082
Thirst or dry mouth	Control	0.11	0.08	0.271	0.082
Shortness of breath	Intervention	0.18	0.08	0.069	0.935
Shortness of breath	Control	0.15	0.08	0.111	0.935
Clumsiness or difficulty with balance	Intervention	−0.03	0.08	0.771	0.184
Clumsiness or difficulty with balance	Control	0.15	0.07	0.081	0.184
Fever, night sweats, or chills	Intervention	0.02	0.08	0.863	0.844
Fever, night sweats, or chills	Control	0.08	0.07	0.431	0.844
Constipation, gas, or bloating	Intervention	0.25	0.09	0.018	0.935
Constipation, gas, or bloating	Control	0.28	0.08	0.004	0.935
Diarrhea	Intervention	0.18	0.08	0.069	0.968
Diarrhea	Control	0.18	0.08	0.041	0.968
Cough	Intervention	−0.01	0.09	0.959	0.844
Cough	Control	0.06	0.08	0.577	0.844
Speech difficulties	Intervention	−0.16	0.05	0.010	0.013
Speech difficulties	Control	0.09	0.05	0.123	0.013
Difficulty remembering	Intervention	0.16	0.08	0.111	0.935
Difficulty remembering	Control	0.13	0.08	0.168	0.935
Heartburn	Intervention	0.08	0.08	0.448	0.535
Heartburn	Control	0.19	0.07	0.023	0.535
Changes in appetite	Intervention	0.12	0.08	0.233	0.882
Changes in appetite	Control	0.07	0.07	0.444	0.882
Dry eyes	Intervention	0.28	0.07	0.001	0.076
Dry eyes	Control	0.04	0.07	0.637	0.076
Problems achieving or maintaining erection	Intervention	0.15	0.10	0.258	0.712
Problems achieving or maintaining erection	Control	0.02	0.13	0.920	0.712
Neuropathy	Intervention	0.14	0.09	0.233	0.844
Neuropathy	Control	0.07	0.09	0.567	0.844
Pain or discomfort during sex	Intervention	−0.12	0.05	0.069	0.129
Pain or discomfort during sex	Control	0.02	0.05	0.741	0.129
Ringing in ears or noise intolerance	Intervention	0.17	0.07	0.029	0.076
Ringing in ears or noise intolerance	Control	−0.07	0.06	0.431	0.076
Difficulty with urination	Intervention	0.02	0.07	0.876	0.712
Difficulty with urination	Control	−0.06	0.06	0.480	0.712
Nausea or vomiting	Intervention	0.15	0.07	0.069	0.414
Nausea or vomiting	Control	0.03	0.06	0.743	0.414

The estimates for each variable listed here were not controlled for baseline characteristics. When baseline characteristics (age, sex, race) were controlled for, no changes were observed.

Positive estimate indicates that the symptom score decreased from period 1 to period 3

Test for difference in mean score change from period 1 to period 3 by intervention arms. All p values were adjusted for multiple tests by controlling false discovery rate (FDR) at 0.05.

Test for difference in mean score change from period 1 to period 3 between 2 arms. All p values were adjusted for multiple tests by controlling false discovery rate (FDR) at 0.05.