. Author manuscript; available in PMC: 2022 May 1.

Published in final edited form as: Pharm Stat. 2021 Jan 19;20(3):573–596. doi: 10.1002/pst.2095

Table 3.

Eight subgroup virtual responses under virtual treatment effect scenarios

Scenario^*	Treatment	Subgroup 1	Subgroup 2	Subgroup 3	Subgroup 4	Subgroup 5	Subgroup 6	Subgroup 7	Subgroup 8
No effect	A	0	0	0	0	0	0	0	0
No effect	B	0	0	0	0	0	0	0	0

Moderate and homogeneous effect	A	0	0	0	0	0	0	0	0
Moderate and homogeneous effect	B	0.17	0.17	0.17	0.17	0.17	0.17	0.17	0.17

Small and homogeneous effect	A	0	0	0	0	0	0	0	0
Small and homogeneous effect	B	0.085	0.085	0.085	0.085	0.085	0.085	0.085	0.085

Spread	A	0	0	0	0	0	0	0	0
Spread	B	0.05	0.075	0.1	0.125	0.15	0.175	0.2	0.225

Opposite	A	0.17	0.17	0	0	0.17	0.17	0	0
Opposite	B	0	0	0.17	0.17	0	0	0.17	0.17

One nugget	A	0	0	0	0	0	0	0	0
One nugget	B	0	0.17	0	0	0	0	0	0

: The standard deviation of each subgroup virtual response for each scenario is 0.3.