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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Curr Opin Genet Dev. 2020 Dec 5;67:67–76. doi: 10.1016/j.gde.2020.11.002

Figure 4:

Figure 4:

Model of nuclear speckle functions: Proximity to speckles results in increased transcription, splicing, and export-competence. The diagram depicts a model in which nuclear speckle-proximal genes are highly expressed and their RI-RNAs are able to diffuse into speckles for post-transcriptional splicing and export, whereas speckle-distant genes are lowly expressed and their RI-RNAs are fated for decay. Not depicted but discussed in the text is the idea that nuclear speckles also promote co-transcriptional splicing.