Table 2.

Univariate and multivariable cox proportional analyses for non-GBM related death in elderly patients with glioblastoma.

	Univariate analysis		Multivariable analysis
	HR (95%CI)	P value	HR (95%CI)	P value
Age
< 75	1 [Reference]		1 [Reference]
≥ 75	2.17 (1.67–2.81)	< 0.001†	1.95 (1.48–2.60)	< 0.001†
Sex
Female	1 [Reference]		1 [Reference]
Male	1.24 (0.95–1.61)	0.105	1.45 (1.09–1.93)	0.009†
Race
Other	1 [Reference]		1 [Reference]
Black	1.59 (0.79–3.19)	0.194	1.45 (0.71–2.98)	0.306
White	0.81 (0.47–1.39)	0.446	0.85 (0.49–1.49)	0.586
Marital status
Single	1 [Reference]		1 [Reference]
Divorced/separated	0.90 (0.53–1.54)	0.706	1.14 (0.66–1.95)	0.634
Married/partner	0.51 (0.34–0.77)	0.002	0.61 (0.40–0.94)	0.023†
Widowed	0.74 (0.45–1.21)	0.244	0.74 (0.45–1.21)	0.244
Insurance status
Insured	1 [Reference]		1 [Reference]
Medicaid	0.44 (0.30–0.64)	< 0.001†	0.53 (0.36–0.79)	< 0.002†
Uninsured	/	/	/	/
Primary site
Temporal	1 [Reference]		1 [Reference]
Brainstem	/	/	/	/
Cerebellum	0.62 (0.09–4.42)	0.630†	0.43 (0.06–3.15)	0.409
Cerebrum	1.97 (0.79–4.85)	0.143	1.49 (0.59–3.73)	0.400
Frontal	0.87 (0.62–1.23)	0.445	0.85 (0.60–1.19)	0.341
Occipital	1.09 (0.64–1.87)	0.755	1.11 (0.65–1.90)	0.710
Overlapping	0.93 (0.60–1.42)	0.722	0.90 (0.59–1.39)	0.641
Parietal	1.14 (0.80–1.63)	0.477	1.05 (0.73–1.51)	0.792
Ventricle	/	/	/	/
Size
≤ 5.4	1 [Reference]		1 [Reference]
> 5.4	1.07 (0.79–1.46)	0.652	1.18 (0.86–1.61)	0.300
Metastasis
No	1 [Reference]		1 [Reference]
Yes	3.01 (1.32–6.87)	0.009	2.33 (0.99–5.47)	0.052
Surgery
Biopsy	1 [Reference]		1 [Reference]
GTR	0.60 (0.45–0.81)	0.001†	0.67 (0.49–0.90)	0.010†
STR	0.75 (0.53–1.07)	0.116	0.87 (0.61–1.25)	0.461
Adjuvant therapy
No/unknown	1 [Reference]		1 [Reference]
Both	0.23 (0.16–0.31)	< 0.001†	0.27 (0.20–0.37)	< 0.001†
Chemotherapy	0.24 (0.09–0.65)	0.005†	0.24 (0.09–0.68)	0.007†
Radiotherapy	0.56 (0.37–0.85)	0.007†	0.55 (0.36–0.84)	0.006†

GTR gross total resection, STR subtotal resection.

^†P < 0.05, statistically significant;