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. 2021 Apr 29;11:9322. doi: 10.1038/s41598-021-88614-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparison of VP1 amino acids of AAV.GT5 with AAV2, AAV3A, and AAV3B. Surface variable regions (VR-1 to VR-IX) are boxed. Amino acid residues that bind to heparan sulfate are indicated with ellipse. Epitopes of antibodies against AAV2 (A20, D3, and C37-B) are underlined. Substitution of three amino acids, S472A, S587A, and N706A, on the surface loop of AAV3 are shown in red. Amino acids in AAV2 and AAV3A that are different from those in AAV3B are shown in blue and green, respectively.