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. 2021 Apr 29;11:9322. doi: 10.1038/s41598-021-88614-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Visualization of AAV vectors transduction of human hepatocytes in a chimeric mouse liver. Representative images of hepatocytes in PXB mice that received 1.0 × 10¹¹ vg/mouse of AAV3B or AAV.GT5 expressing GFP. Green stain, GFP; red stain, human hepatocytes (CK8/18 +). Scale bar represents 30 μm. (b) Comparison of transduction efficacies of AAV3B and AAV.GT5 by quantifying the percent GFP + human hepatocytes in liver sections. The black circles represent the efficiency for each mouse, and the bars represent the average. *P = 0.00001.