Fig. 6. Silencing CCR2 reverts enhanced leukocyte infiltration in GILZ KO mouse livers.

A The number of leukocytes isolated from the livers of 4-month-old WT and GILZ KO mice that had been pretreated with siCCR2 or siLUC (LUC) for 1 week and then treated with oil (control) or CCl₄ for 72 h. B Immunohistochemical analysis of α-SMA expression in the liver sections of WT and GILZ KO mice that had been pretreated with siLUC or siCCR2, and then treated with oil or CCl₄ for 72 h. Arrows indicate the areas of α-SMA positivity. Original magnification, 5×; scale bar, 200 µM. Results are presented as the means ± SEM. Each dot represents an individual mouse; scale bars indicate the mean. Data were pooled from two independent experiments (**p < 0.005, ns not significant).