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. 2021 Apr 29;12(5):421. doi: 10.1038/s41419-021-03704-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — TSC22D3 and CCL2 mRNA expression was analyzed in liver samples from NAFLD patients, according to GSE48452 (NASH patients) and GSE49541 (NAFLD patients) cohorts accessed in Gene Expression Omnibus. A, B TSC22D3 mRNA expression in NASH patients. Samples were classified as A high fat score when presenting a score of ≥70 (n = 9) and B fibrosis stages 1–4, representing the samples in this score range (n = 14). C, D TSC22D3 (C) and CCL2 (D) gene expression in NAFLD patients with mild (stages 0–1; n = 40) and advanced (stages 3–4; n = 34) fibrosis. E, F Pearson correlation between TSC22D3 and CCL2 mRNA expression in NAFLD patients. E Pearson correlation coefficient in NAFLD patients with mild (stages 0–1) and (F) advanced (stages 3–4) fibrosis. Data are presented as a box and whiskers plot. *p < 0.05, **p < 0.01.