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. Author manuscript; available in PMC: 2022 May 1.
Published in final edited form as: Depress Anxiety. 2021 Feb 23;38(5):488–497. doi: 10.1002/da.23142

Figure 1.

Figure 1.

A) Whole-brain analysis of covariance with rumination assessed with the Ruminative Response Scale (RRS) and worry assessed with the Penn State Worry Questionnaire (PSWQ) as covariates of interest showing left amygdala-left dorsolateral prefrontal cortex extending to left inferior frontal gyrus (DLPFC/IFG) parameter estimates of functional connectivity, controlling for symptom severity with the Hamilton Depression Rating scale (HAMD) and Hamilton Anxiety Rating scale (HAMA) on a statistical t-map at p<0.001. B) Scatterplot of regression analyses depicting extracted parameter estimates of left amygdala-DLPFC/IFG and relationship to RRS, controlling for HAMA and HAMD, illustrating greater connectivity is associated with more rumination (higher RRS total scores). C) Scatterplot of regression analyses depicting extracted parameter estimates of left amygdala-DLPFC/IFG and relationship to PSWQ, controlling for HAMA and HAMD, showing greater connectivity is associated with more worry (higher PSWQ total scores).