Table 2.

Breast cancer risk assessment (case–control) of previously identified variant alleles.

SNV ID	Associated/neighboring genes	Minor allele	Overall BC risk (all samples)						SIR African Americans			SIR Ghanaians
			Models without covariates			Models with covariates*			Models with covariates**			Models with covariates**
			N	OR (95% CI)	P value	N	OR (95% CI)	P value	N	OR (95% CI)	P value	N	OR (95% CI)	P value
rs13000023	TNP1, DIRC3	A	420	1.048 (0.756, 1.449)	0.775	271	1.061 (0.601, 1.874)	0.838	104	–	–	75	0.909 (0.466, 1.770)	0.780
rs2363956	ANKLE1	G	415	0.847 (0.629, 1.140)	0.273	274	1.272 (0.718, 2.254)	0.409	103	0.916 (0.135, 6.197)	0.928	76	1.409 (0.688, 2.890)	0.349
rs2981578	FGFR2	T	416	1.508 (1.111, 2.047)	0.008	267	1.036 (0.611, 1.759)	0.895	99	–	–	78	0.891 (0.481, 1.650)	0.713
rs2981579	FGFR2	G	418	1.246 (0.928, 1.675)	0.144	269	1.899 (1.063, 3.393)	0.030	99	–	–	77	1.792 (0.905, 3.545)	0.095
rs3112572	CASC16, LOC643714	A	385	1.007 (0.691, 1.467)	0.972	246	2.410 (1.086, 5.347)	0.031	96	–	–	65	2.088 (0.948, 4.597)	0.068
rs3745185	BABAM1	A	409	0.666 (0.492, 0.901)	0.008	265	0.618 (0.341, 1.119)	0.112	99	0.787 (0.104, 5.947)	0.816	77	0.590 (0.272, 1.280)	0.182
rs4245739	MDM4	C	409	1.193 (0.860, 1.654)	0.291	264	0.995 (0.569, 1.740)	0.986	97	0.008 (0.000, 20.16)	0.228	75	0.838 (0.427, 1.644)	0.607
rs4849887	LOC84934, GLI2	C	403	1.654 (1.154, 2.371)	0.006	257	0.790 (0.351, 1.776)	0.568	100	0.399 (0.013, 12.43)	0.601	69	0.754 (0.274, 2.073)	0.584
rs609275	MYEOV, CCND1	T	396	1.129 (0.822, 1.552)	0.453	253	1.121 (0.532, 2.361)	0.764	98	0.224 (0.014, 3.646)	0.293	67	0.920 (0.389, 2.176)	0.849

Significant alleles (p value < 0.05) are given in bold and italic

*Overall analysis models with covariates adjusts for age and SIR.

**SIR models with covariates adjusts for age.