Table 4.

Breast cancer risk assessment (case–control) of DARC/ACKR1 alleles.

SNV ID	Associated/neighboring genes	Minor allele	Overall BC risk (all samples)						SIR African Americans			SIR Ghanaians
			Models without covariates			Models with covariates*			Models with covariates**			Models with covariates**
			N	OR (95% CI)	P value	N	OR (95% CI)	P value	N	OR (95% CI)	P value	N	OR (95% CI)	P value
rs6676002	DARC/ACKR1	T	282	1.290 (0.702, 2.368)	0.412	231	0.634 (0.164, 2.454)	0.509	96	–	–	47	–	–
rs3027008	DARC/ACKR1	T	282	1.187 (0.661, 2.131)	0.566	231	0.737 (0.230, 2.369)	0.609	96	–	–	49	2.270 (0.277, 18.60)	0.445
rs3027013	DARC/ACKR1	T	283	0.869 (0.372, 2.033)	0.747	231	0.250 (0.050, 1.241)	0.090	96	–	–	49	–	–
rs71782098	DARC/ACKR1	DEL	291	0.575 (0.307, 1.077)	0.084	238	0.753 (0.280, 2.028)	0.575	96	–	–	52	0.882 (0.298, 2.608)	0.820
rs2814778	DARC/ACKR1	C	712	1.512 (1.263, 1.809)	< 0.001	492	0.772 (0.392, 1.520)	0.454	153	0.696 (0.330, 1.467)	0.340	54	3.657 (0.231, 57.81)	0.357
rs17838198	DARC/ACKR1	T	299	4.798 (2.125, 10.83)	< 0.001	244	3.413 (0.678, 17.20)	0.137	97	1.052 (0.044, 25.41)	0.975	58	–	–
rs3027016	DARC/ACKR1	G	281	4.586 (1.587, 13.26)	0.005	229	2.311 (0.269, 19.88)	0.446	96	–	–	47	–	–
rs12075	DARC/ACKR1	G	292	2.534 (1.498, 4.287)	< 0.001	238	1.131 (0.382, 3.351)	0.824	97	1.108 (0.048, 25.80)	0.949	53	–	–

Significant alleles (p value < 0.05) are given in bold and italic

*Overall analysis models with covariates adjusts for age and SIR.

**SIR models with covariates adjusts for age.