Table 5.
TNBC-specific risk assessment (case-series) of DARC/ACKR1 alleles.
| SNV ID | Associated/neighboring genes | Minor Allele | Overall TNBC risk (all samples) | SIR African Americans | SIR Ghanaians | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Models without covariates | Models with covariates* | Models with covariates** Models with covariates** | Models with covariates*** | |||||||||||
| N | OR (95% CI) | P value | N | OR (95% CI) | P value | N | OR (95% CI) | P value | N | OR (95% CI) | P value | |||
| rs6676002 | DARC/ACKR1 | T | 176 | 0.191 (0.058, 0.635) | 0.007 | 175 | 0.403 (0.111, 1.460) | 0.167 | 90 | – | – | 2 | – | – |
| rs3027008 | DARC/ACKR1 | T | 174 | 0.134 (0.032, 0.568) | 0.006 | 173 | 0.275 (0.060, 1.261) | 0.097 | 90 | – | – | 2 | – | – |
| rs3027013 | DARC/ACKR1 | T | 174 | – | – | 173 | – | – | 90 | – | – | 2 | – | – |
| rs71782098 | DARC/ACKR1 | DEL | 178 | 3.403 (1.231, 9.412) | 0.018 | 177 | 2.629 (0.796, 8.682) | 0.112 | 90 | 2.547 (0.668, 9.716) | 0.171 | 2 | – | – |
| rs2814778 | DARC/ACKR1 | C | 339 | 3.062 (2.249, 4.168) | < 0.001 | 304 | 3.814 (1.710, 8.493) | 0.001 | 95 | 3.368 (1.390, 8.165) | 0.007 | 16 | – | – |
| rs17838198 | DARC/ACKR1 | T | 178 | 0.367 (0.164, 0.821) | 0.015 | 177 | 0.929 (0.355, 2.430) | 0.881 | 91 | 0.722 (0.190, 2.754) | 0.634 | 2 | – | – |
| rs3027016 | DARC/ACKR1 | G | 174 | 0.390 (0.144, 1.058) | 0.065 | 173 | 0.839 (0.270, 2.609) | 0.762 | 90 | 1.204 (0.226, 6.422) | 0.828 | 2 | – | – |
| rs12075 | DARC/ACKR1 | G | 177 | 0.380 (0.199, 0.726) | 0.003 | 176 | 0.846 (0.396, 1.807) | 0.666 | 91 | 0.922 (0.319, 2.669) | 0.881 | 2 | – | – |
Significant alleles (p value < 0.05) are given in bold and italic
*Overall analysis models with covariates adjusts for age and SIR.
**SIR AA models with covariates adjusts for age and West African ancestry.
***SIR Ghanaian models with covariates adjusts for age.