(A) A μCT imaging showing the healed extraction socket on PED21. (B) A representative tissue section stained with pentachrome showing that keratinized OE covered the healed mxM1 extraction site by PED21. (C) Compared to the JE around mxM2, healed OE exhibited low levels of Laminin5. (D) Site preparation for implant placement. The healing of the soft tissue around implant were examined by pentachrome staining on (E) PID1, (F) PID3, (G) PID7, and (H) PID14. (I) A representative tissue section stained with pentachrome showing the intact JE around tooth. Dotted white lines indicate the demarcation between the epithelium and connective tissue. Abbreviations: as in Fig. 1 and IM, implant; PIE, peri-implant epithelium. Scale bars: 50 μm.