Table 1.
Line | References | Recombination in microglia | Recombination in CAMs | Recombination in nonmyeloid CNS cells | Recombination in blood cells |
---|---|---|---|---|---|
Cx3crlCnERT2 | 168–170 | High | High | No | Transient, high in blood monocytes |
Csf1rMer-iCre-Mer | 28,32 | High | Unknown | In a small subset of embryonic endothelial cells, EMPs | Transient, high in blood monocytes |
Sall1CreERT2 | 40,171, 176, 177, 190 | High | No | Relatively high in astrocytes and oligodendrocytes, lower in neurons | No |
Tmeml19CreERT2 | 173 | High | No | CD31+ endothelial cells, perivascular fibroblasts, meningeal fibroblasts | Transient (?), very low in CD45+ cells |
HexbCreERT2 | 171 | High | Very low | No | Transient, very low in monocytes, granulocytes |
P2ryl2CreERT2 | 175 | High | Very low (dura) | No | No |
This table does not include all mouse lines ever used in microglial research. Lines with constitutive Cre expression (e.g., Cx3cr1GFP, Siglec1Cre, VaviCre), poor recombination in microglia in general (e.g., LysmCre, Flt3Cre), or applications in early hematopoietic fate mapping during embryogenesis (e.g., Runx1CreERT2, Cdh5CreERT2) are not included. Abbreviations: CAM, CNS-associated macrophage; CNS, central nervous system; EMP, erythromyeloid precursor.