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. 2021 Apr 29;11:9335. doi: 10.1038/s41598-021-88599-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Paroxetine effects in the open field. (A) (Left) Cumulative distance moved in the open field. (Middle and right) Mean (± SD) distance after 5 (middle) and 10 min (right). White circles show data for individual animals. Animals were treated with vehicle or paroxetine (10 mg/kg) 1 h prior to behavioral testing. (B–D) As before, but for the time spent moving (B), number of entries in the center zone (C) and time spent there (D). Paroxetine increased locomotor activity and did not majorly influence the exploration of the center zone. ^#p < 0.05, *p < 0.01, two-sample t-test.