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. 2021 Apr 29;11:9223. doi: 10.1038/s41598-021-88560-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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WNT2 was downregulated and miR-383 was upregulated in hippocampi tissues of chronic unpredictable mild stress (CUMS)-induced rats. (A,B) The mRNA level (A) and protein level (B) of Wnt2 in hippocampal tissues of CUMS-induced rats and control group. (C) The mRNA level of miRNAs in hippocampal tissues of CUMS-induced rats and control group. (D) The mRNA level of miR-383 in hippocampal tissues of CUMS-induced rats and control group. (E) The correlation between miR-383 level and Wnt2 level was evaluated by Pearson’s analysis. N = 6. Data were presented as mean ± SD and each experiment was repeated three times. *P < 0.05, **P < 0.01.