Table 1.
B12-Specific Enzymes Used for the Identification of B12-Dependent Pathways in Fungal Proteomes with the Total Number of Homologs Identified in This Study
| Human Gene | EC | Enzyme Name | Reference | Pfam Name | Pfam ID | Structure ID | No. of Fungal Proteins | No. of Fungal Species |
|---|---|---|---|---|---|---|---|---|
| MUT | 5.4.99.2 | Methylmalonyl-CoA mutase, MM-CoA mutase | Forny et al. (2014) | MM_CoA_mutase | PF01642 | 2XIJ | 39 | 36 |
| MCEE | 5.1.99.1 | Methylmalonyl-CoA epimerase, MM-CoA epimerase | Bobik and Rasche (2001) | Glyoxalase_4 | PF13669 | 1JC5 | 42 | 32 |
| MMAA | 3.6.5. | Methylmalonyl Co-A mutase-associated GTPase, MeaB | Bobik and Rasche (2001); Froese et al. (2010) | MeaB | PF03308 | 2WWW | 30 | 24 |
| MTR | 2.1.1.13 | Methionine synthase, MetH | Bobik and Rasche (2001); Froese et al. (2010); Bassila et al. (2017) | Met_synt_B12 | PF02965 | 2O2K | 65 | 53 |
| MMAB | 2.5.1.17 | Methylmalonic aciduria and homocystinuria type B family, CblAdo transferase | Mera et al. (2007) | Cob_adeno_trans | PF01923 | 2R6X | 71 | 50 |
| MMACHC | 1.16.1.6 | Methylmalonic aciduria and homocystinuria type C family, CblC | Kim et al. (2009) | CblC | PF16690 | 3SBZ | 23 | 20 |
| MMADHC | — | Methylmalonic aciduria and homocystinuria type D family, CblD | Coelho et al. (2008) | CblD | PF10229 | 5CV0 | 55 | 47 |
| — | 1.17.4.2 | Ribonucleoside-diphosphate reductase class II, RNR class II | Booker and Stubbe (1993) | RNR_Alpha | PF17975 | 1L1L | 24 | 13 |