Table 2.
Baseline clinical and neuroimaging characteristics of included patients by IL-6 quartile
| All | Q1 | Q2 | Q3 | Q4 | p | |
|---|---|---|---|---|---|---|
| n | 552 | 142 | 136 | 136 | 138 | |
| Age, year, mean [SD] | 64 [13] | 61 [13] | 64 [13] | 64 [13] | 66 [13] | 0.05 |
| Female, No. (%) | 202 (37) | 56 (39) | 41 (30) | 51 (37) | 55 (40) | 0.31 |
| Hypertension, No. (%) | 467 (93) | 115 (94) | 117 (91) | 125 (95) | 115 (91) | 0.49 |
| Hyperlipidemia, No. (%) | 153 (31) | 40 (33) | 41 (32) | 39 (30) | 34 (27) | 0.83 |
| Diabetes, No. (%) | 60 (12) | 7 (6) | 17 (13) | 18 (14) | 18 (14) | 0.12 |
| Atrial Fibrillation, No. (%) | 19 (4) | 5 (4) | 4 (3) | 5 (4) | 5 (4) | 0.87 |
| Coronary Artery Disease, No. (%) | 28 (6) | 3 (3) | 12 (9) | 8 (6) | 5 (4) | 0.09 |
| COPD, No. (%) | 16 (3) | 3 (3) | 5 (4) | 3 (2) | 5 (4) | 0.78 |
| Systolic BP (mmHg) | 179 (30) | 177 (30) | 177 (27) | 181 (30) | 181 (30) | 0.47 |
| Leukocytes (ug/l) | 9 (3) | 8 (3) | 8 (3) | 9 (3) | 12 (4) | <0.001 |
| Thrombocytes (ug/l) | 240 (60) | 243 (64) | 235 (58) | 241 (73) | 240 (72) | 0.81 |
| Glucose (mg/dl) | 135 (50) | 120 (37) | 133 (46) | 132 (51) | 153 (56) | <0.001 |
| Body Temperature (°C) | 36 (0.6) | 36 (0.6) | 36 (0.6) | 36 (0.6) | 36 (0.7) | 0.57 |
| ICH Location, No. (%) | <0.001 | |||||
| Deep | 433 (81) | 119 (86) | 112 (84) | 115 (85) | 91 (68) | |
| Lobar | 78 (15) | 16 (12) | 12 (9) | 17 (13) | 33 (25) | |
| ICH Volume, mL, mean [SD] | 23.5 [25.7] | 15.6 [16.1] | 17.3 [17.3] | 25.6 [25.4] | 35.6 [34.7] | <0.001 |
| PHE Volume, mL, mean [SD] | 5.4 [3.0] | 4.5 [2.0] | 4.8 [2.3] | 5.2 [3.1] | 6.9 [3.4] | <0.001 |
| IVH present, No (%) | 205 (37) | 47 (34) | 38 (28) | 59 (43) | 61 (44) | 0.01 |
| Treatment Group, No. (%) | 0.84 | |||||
| 20 ug | 172 (31) | 45 (32) | 45 (33) | 40 (29) | 43 (31) | |
| 80 ug | 183 (33) | 42 (30) | 48 (35) | 51 (37) | 46 (33) | |
| Placebo | 197 (35) | 55 (39) | 45 (33) | 47 (34) | 50 (36) |
Abbreviations: ICH = intracerebral hemorrhage, SD = standard deviation, PHE = perihematomal edema