Table 2: vmPFC Seed Functional Connectivity by task, condition, and group comparison.

Regions that demonstrate significant activation above the −log₁₀(p) value cutoff of 1.3010 (where p is 0.05, corrected for multiple comparisons across voxels and contrasts) among Reward (Rew), Punishment (Pun), Mental, and Random conditions for the Gambling and Social tasks, respectively. Sites of functional connectivity activation marked with probabilistic anatomical labels correspond to anatomical coordinates (x,y,z) for each group comparison: major depressive disorder (MDD), family history (FH) and healthy controls (HC).

vmPFC-Cerebellar PPI analyses
Task	Condition	Comparison	Probabilistic Anatomical label	x	y	z	−log10(p)
Gambling	Rew>Pun	MDD>FH	Right Crus I (15%), Right Crus II (5%)	9	−84	−20	1.6307
Gambling	Pun>Rew	FH>MDD	Right Crus I (15%), Right Crus II (5%)	9	−84	−20	1.6307
Social	Mental	MDD>HC	Right VIIa (45%), Right VIIb (45%)	14	−72	−54	1.6497
Social	Mental	FH>HC	Left Crus I (100%)	−47	−68	−36	1.6055
Social	Random	FH>HC	Left Crus I (71%), Left VI (28%)	−36	−61	−28	1.6126
vmPFC-whole brain PPI analyses
Social	Mental	FH>HC	Insular Cortex (39%)	−30	13	6	1.4294
			Left Putamen (98%)	−17	9	−7
			Frontal Pole (78%)	−36	42	25
Social	Random	FH>MDD	Frontal Pole (90%)	−42	53	−3	1.3851