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. Author manuscript; available in PMC: 2022 May 14.
Published in final edited form as: J Mol Biol. 2021 Mar 24;433(10):166953. doi: 10.1016/j.jmb.2021.166953

Figure 2.

Figure 2.

ThT aggregation kinetics of monomeric αS and TDP-43 PrLD in 20 mM MES buffer at pH 6.0 a) ThT fluorescence of 20 μM αS (△) in presence of 0.05 to 1 molar ratio of TDP-43 PrLD to αS (●) and respective TDP-43 PrLD controls (○). b) ThT fluorescence of 20 μM TDP-43 PrLD (○) in presence of 0.05 to 2 molar ratio of αS to TDP-43 PrLD (●) and respective αS controls (△). The data were fit with Boltzmann’s sigmoidal function (see Materials and Methods) to derive lag time information.