Table 4:
Cytokine Concentration by Transplant Status
| Cytokine Concentration (by Transplant Status) | ||||||
|---|---|---|---|---|---|---|
| Transplant GNB (N=29) | Non- Transplant GNB (N=30) | p value | Transplant SAB (N=26) | Non-Transplant GNB (N=30) | p value | |
| Eotaxin, Median (IQR) | 34.9 (23.4, 39.9) | 37.8 (24.5, 44.0) | 0.511 | 52.7 (32.5, 87.4) | 54.9 (39.9, 89.4) | 0.851 |
| IFN-α, Median (IQR) | 5.1 (5.1, 5.1) | 5.1 (5.1, 26.3) | 0.041 | 5.1 (5.1, 36.4) | 5.1 (5.1, 24.0) | 0.381 |
| IL-1RA, Median (IQR) | 331.3 (194.4, 699.8) | 566.1 (365.4, 1826.0) | 0.061 | 842.2 (411.9, 1712.8) | 748.7 (509.9, 1942.2) | 0.791 |
| IL-10, Median (IQR) | 6.0 (6.0, 6.0) | 6.0 (6.0, 6.0) | 0.671 | 6.0 (6.0, 34.2) | 6.0 (6.0, 33.3) | 0.801 |
| IL-12, Median (IQR) | 81.6 (47.3, 134.4) | 68.6 (34.3, 103.2) | 0.401 | 84.8 (40.6, 235.6) | 138.3 (75.0, 333.0) | 0.191 |
| IL-15, Median (IQR) | 12.0 (12.0, 12.0) | 12.0 (12.0, 126.7) | 0.031 | 11.3 (11.3, 92.4) | 11.3 (11.3, 92.4) | 0.911 |
| IL-2, Median (IQR) | 7.1 (7.1, 7.1) | 32.6 (7.1, 88.0) | 0.0011 | 6.9 (6.9, 95.9) | 28.6 (6.9, 98.8) | 0.861 |
| IL-2R, Median (IQR) | 74.6 (28.5, 189.1) | 134.3 (28.5, 298.4) | 0.461 | 266.9 (120.8, 467.4) | 221.1 (28.4, 330.6) | 0.481 |
| IL-6, Median (IQR) | 25.9 (3.5, 86.5) | 38.7 (15.8, 97.2) | 0.211 | 56.2 (15.6, 97.7) | 72.7 (34.0, 102.3) | 0.281 |
| IL-8, Median (IQR) | 32.0 (5.6, 53.1) | 59.1 (39.2, 119.4) | 0.0031 | 84.4 (38.7, 114.8) | 103.0 (62.5, 254.4) | 0.091 |
| IP-10, Median (IQR) | 6.8 (4.2, 12.7) | 6.2 (3.8, 11.9) | 0.741 | 6.9 (4.3, 16.2) | 10.1 (3.9, 17.1) | 0.801 |
| MCP-1, Median (IQR) | 496.5 (291.1, 728.4) | 448.6 (355.8, 807.7) | 0.841 | 736.5 (412.7, 1142.8) | 912.7 (469.2, 1458.9) | 0.511 |
| MIG, Median (IQR) | 82.7 (65.2, 226.0) | 75.9 (13.1, 139.1) | 0.431 | 204.6 (72.0, 357.1) | 149.1 (94.0, 211.7) | 0.361 |
| MIP-1α, Median (IQR) | 8.9 (8.9, 8.9) | 8.9 (8.9, 8.9) | 0.211 | 8.8 (8.8, 49.1) | 8.8 (8.8, 44.8) | 0.861 |
| MIP-1β, Median (IQR) | 30.7 (30.7, 30.7) | 243.3 (30.7, 344.4) | 0.0011 | 193.6 (88.0, 362.7) | 234.3 (131.0, 444.8) | 0.291 |
| RANTES, Mean (SD) | 544.8 (106.5) | 523.4 (137.3) | 0.512 | 750.2 (194.6) | 656.5 (147.6) | 0.0462 |
| GM-CSF, Median (IQR) | 3.5 (3.5, 3.5) | 3.5 (3.5, 3.5) | 0.621 | 3.5 (3.5, 3.5) | 3.5 (3.5, 3.5) | 0.321 |
| IFN-γ, Median (IQR) | 3.0 (3.0, 3.0) | 3.0 (3.0, 3.0) | 0.341 | 3.0 (3.0, 3.0) | 3.0 (3.0, 3.0) | 0.381 |
| IL-1β, Median (IQR) | 6.1 (6.1, 6.1) | 6.1 (6.1, 6.1) | 0.331 | 6.0 (6.0, 6.0) | 6.0 (6.0, 6.0) | 0.291 |
| IL-13, Median (IQR) | 7.2 (7.2, 7.2) | 7.2 (7.2, 7.2) | .2 | 6.9 (6.9, 6.9) | 6.9 (6.9, 6.9) | 0.921 |
| IL-17A, Median (IQR) | 14.9 (14.9, 14.9) | 14.9 (14.9, 14.9) | .2 | 14.9 (14.9, 14.9) | 14.9 (14.9, 14.9) | 0.301 |
| IL-4, Median (IQR) | 31.4 (31.4, 31.4) | 31.4 (31.4, 31.4) | 0.331 | 30.6 (30.6, 30.6) | 30.6 (30.6, 30.6) | 0.731 |
| IL-5, Median (IQR) | 5.1 (5.1, 5.1) | 5.1 (5.1, 5.1) | .2 | 5.0 (5.0, 5.0) | 5.0 (5.0, 5.0) | .2 |
| IL-7, Median (IQR) | 9.4 (9.4, 9.4) | 9.4 (9.4, 9.4) | 0.321 | 9.0 (9.0, 9.0) | 9.0 (9.0, 9.0) | 0.291 |
| TNF-α, Median (IQR) | 2.9 (2.9, 2.9) | 2.9 (2.9, 2.9) | 0.331 | 2.8 (2.8, 2.8) | 2.8 (2.8, 2.8) | 0.921 |
GNB, gram-negative bacteremia; SAB, S. aureus bacteremia;
1
Wilcoxon
2
Equal Variance T-Test