Table 3.

Disease states and recommended actions in each state.

Disease state					Estimated Total UPDRS at $t_2$	Actions
						clinicians			AI
State	Subtype	Total UPDRS at $t_1$	% UPDRS change	Age		L	D	O	L	D	O
0	AR	( , 8]			10.2			×			×
1	AR	[9, 11]	[− 25.6, )		11.9		×
2	AR	[12, 14]	[− 25.6, )		14.7		×	×	×	×	×
3	AR	[15,17]	[− 12.7, )		17.0		×			×
4	AR	[9,14]	( , − 25.6]		17.1	×		×	×		×
5	AR	[18,19]	[− 12.7, )		19.3		×	×		×	×
6	AR	[20,24]	[16.2, )		20.0	×		×	×	×
7	AR	[15,19]	( , − 12.7]		21.9		×	×	×	×
8	AR	[20,24]	(− 14.6, 16.228]	[65, )	23.4	×	×	×	×	×	×
9	AR	[20,24]	(− 14.6, 16.228]	( , 64]	24.0	×	×			×
10	AR	[25,33]	(39.6, )		25.1		×	×		×	×
11	AR	[20,24]	( , − 14.6]		26.6	×	×	×	×	×	×
12	AR	[25,28]	( − 7.28, 11.8]		27.5	×	×	×		×
13	AR	[25,33]	( 11.8, 39.6]		27.7	×	×		×	×
14	AR	[25,28]	( , − 7.28]		29.5	×	×	×	×		×
15	AR	[29,33]	(− 3.1, 11.8]		30.5	×	×	×	×	×	×
16	AR	[34,39]	(10.6, )		31.3	×	×	×	×	×	×
17	AR	[29,33]	( , − 3.1]		32.5	×	×	×	×	×	×
18	AR	[34,39]	( , 10.6]		36.8		×	×		×	×
19	AR	[40,45]			37.9	×	×	×		×
20	AR	[46, )			46.5	×	×	×	×	×	×
21	Mixed	( ,16]			13.5		×	×	×
22	Mixed	[17,24]			21.3	×	×	×	×
23	Mixed	[25, )			32.1	×		×	×		×
24	TD	( , 14]			11.8		×			×
25	TD	[15,19]			19.0	×		×	×	×
26	TD	[20,28]			23.0	×		×	×		×
27	TD	[29, )			33.1	×	×	×	×	×	×

L Levodopa, D dopamine agonist, O other medicine, AR Akinetic-rigid, TD tremor-dominant.