Table 5.

Enriched functional term clusters following DAVID analysis of genes identified by ROH analysis in candidate regions that were specific to the non-infected cohort and those that overlapped between at least two methods of detecting selection signatures.

	Cluster	Score	Category	Term	Gene count	P-value	Genes	Benjamini
ROH regions specific to non-infected cohorts = 51 genes	1	2.19	INTERPRO	IPR001325:Interleukin-4/interleukin-13	3	0.00003	IL4, IL13	0.002
			INTERPRO	IPR018096:Interleukin-4/interleukin-13, conserved site	3	0.00003	IL4, IL13	0.002
			SMART	SM00190:IL4_13	3	0.00004	IL4, IL13	0.002
			KEGG	oas04060:Cytokine-cytokine receptor interaction	6	0.00056	IL4, CXCR1, CXCR2, IL13, AMH	0.057
			KEGG	oas05310:Asthma	3	0.00638	IL4, IL13	0.326
			INTERPRO	IPR012351:Four-helical cytokine, core	3	0.01402	IL4, IL13	0.364
			INTERPRO	IPR009079:Four-helical cytokine-like, core	3	0.01551	IL4, IL13	0.364
			KEGG	oas04664:Fc epsilon RI signaling pathway	3	0.01706	IL4, IL13	0.580
			KEGG	oas05321:Inflammatory bowel disease (IBD)	3	0.02290	IL4, IL13	0.584
			KEGG	oas05162:Measles	3	0.06509	IL4, IL13	1.000
			KEGG	oas04630:Jak-STAT signaling pathway	3	0.09399	IL4, IL13	1.000
			UP_KEYWORDS	Signal	8	0.52067	IL4, PDF, CDH1, IL13, AMH, TMED6, TMCO1	1.000
			GOTERM_CC	GO:0005615 extracellular space	3	0.67367	IL4, IL13	1.000
	2	1.73	KEGG	oas04060:Cytokine-cytokine receptor interaction	6	0.00056	IL4, CXCR1, CXCR2, IL13, AMH	0.057
			UP_KEYWORDS	Growth factor	4	0.00161	IL4, PDGFD, AMH	0.074
			UP_KEYWORDS	Secreted	3	0.32286	IL4, AMH	1.000
			UP_KEYWORDS	Disulfide bond	5	0.39333	IL4, TMPRSS9, LOC101115991, AMH	1.000
Overlapping genes = 56 genes (excluding ENSOARG genes	1	3.00	INTERPRO	IPR019826: Carboxylesterase type B, active site	3	0.00022	CES3, CES4A, CES2	0.028
			INTERPRO	IPR002018:Carboxylesterase, type B	3	0.00070	CES3, CES4A, CES2	0.045
			GOTERM_MF	GO:0016787 hydrolase activity	4	0.00118	CES3, NUDT6, CES4A, CES2	0.051
			UP_KEYWORDS	Hydrolase	7	0.00520	DDX47, ATP10D, CES3, PCSK5, NUDT6, CES4A, CES2	0.192