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. 2021 Apr 29;11(4):84. doi: 10.1038/s41408-021-00469-5

Fig. 3. The depiction of different generations of CAR T cell.

Fig. 3

First-generation CAR contains basic design with the ScFV portion of monoclonal antibody at the ectodomain, hinge at the transmembrane domain and CD3ζ signaling molecule at the endodomain. Second- and third-generation CARs comprise additional one or two co-stimulatory molecule/s in the endodomain, respectively. Fourth-generation CAR (TRUCK) follows the basic design of second-generation CAR, coupled with an added transgene encoding for a cytokine (transgenic protein).