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Timeline of our understanding of the extracellular matrix (ECM).
| Date | Information | References |
|---|---|---|
| 1700 | “Fiber theory”: tissues and organs are formed by connective tissue arose spontaneously | (7) |
| 1809 | Life can originate only from another life | (7) |
| 1850 | “Cellular theory”: cells do not exist without other cells | (7) |
| ~1900 | Collagen and elastin fibers identification | (7) |
| 1930–1973 | Connective tissue characterization | (7) |
| Last 40 years | Biological functions of the specific ECM components | (1–10) |
