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MMPs inhibitors and their preferential substrates.
| Inhibitory enzymes | Preferential substrate | References | ||||
|---|---|---|---|---|---|---|
| TIMPs | PRO-MMPs | MMPs | MT-MMPs | ADAMs | ADAMTS | |
| TIMP-1 | PRO-MMP-9 | MMP-1 MMP-2 MMP-3 MMP-9 MMP-19 |
MT1-MMP MT3-MMP MT5-MMP |
ADAM-10 | – | (11, 126–133) |
| TIMP-2 | PRO-MMP-2 | MMP-2 | – | – | – | (11, 126–133) |
| TIMP-3 | PRO-MMP-9 PRO-MMP-2 |
MMP-1 MMP-2 MMP-3 MMP-9 MMP-13 |
– | ADAM-12 ADAM-17 |
ADAMTS-1 ADAMTS-4 ADAMTS-5 |
(126–133) |
| TIMP-4 | PRO-MMP-2 | MMP-2 | MT1-MMP | – | (124–133) | |
