Table 1.
Recent efforts in the design of drug delivery methods for anti-pseudomonal therapies.
Chemical nature | Avr. Particle size (nm) | Cell type | Effect | |
---|---|---|---|---|
Anionic liposome | 100 | Planktonic | No difference between capsulated and free abx | Wang et al., 2018 |
100 | Biofilm | Enhanced biofilm eradication | Zahra et al., 2017 | |
625 - 806.6 | Planktonic and biofilm | Prevents biofilm formation | Alhariri et al., 2017 | |
Graphene-oxide conjugates | N/A | Biofilm | Enhanced biofilm eradication | Dai et al., 2018 |
Poly(lactic-co-glycolic) acid nanoparticles | 229.4 - 469.2 | Planktonic | No difference between capsulated and free abx | Hill et al., 2019 |
132 - 348 | Planktonic and biofilm | Prevents biofilm formation | Shaaban et al., 2017 | |
Solid lipid nanoparticles | 200 - 500 | Planktonic | No difference between capsulated and free abx | Severino et al., 2017 |
Water-soluble chitosan oligosaccharide conjugates | N/A | Biofilm | Enhanced biofilm eradication | Li et al., 2019 |