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. 2021 Apr 16;9:635815. doi: 10.3389/fped.2021.635815

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Copyright © 2021 Dirks, Fischer, Haase, Holl-Wieden, Hofmann, Girschick and Morbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of peripheral blood B cell population in ANA-positive and ANA-negative JIA patients. (A) Frequency of peripheral blood CD19⁺ B cells within lymphocytes as well as different B cell populations within CD19⁺ B cells in a cohort of JIA patients (n = 45) and same number of age- and sex-matched healthy control (HC) individuals. Bars represent mean frequency with standard deviation and circles individual data points. (B) Frequency of these B cell populations from JIA patients was compared between ANA+ and ANA– patients. Groups were compared using unpaired Student's t-test.