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. 2021 Apr 16;9:635815. doi: 10.3389/fped.2021.635815

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Copyright © 2021 Dirks, Fischer, Haase, Holl-Wieden, Hofmann, Girschick and Morbach.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Distribution of synovial fluid B cell populations in ANA positive and negative JIA patients. (A) Representative contour plots showing the distribution of different B cell subpopulations as assessed by expression of CD21, CD27, and IgM in an ANA– and an ANA+ JIA patient. (B) Distribution of different B cell population within SF CD19⁺ B cell was analyzed using flow cytometry and compared between ANA– (n = 14) and ANA+ (n = 25) JIA patients (unpaired Student's t-test). Bars represent mean frequency with standard deviation and circles individual data points. N, naïve; NSM, non-switched memory; SM, switched memory, DN, double negative; PC, plasma cells.