Table 2.
Correlation analysis between PERK and related gene markers of innate immune cells in TIMER in BRCA, HNSC, and THCA.
| Description | Gene markers | BRCA (n = 1093) | HNSC (n = 520) | THCA (n = 501) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Purity | None | Purity | None | Purity | None | ||||||||
| Cor | p | Cor | P | Cor | p | Cor | p | Cor | p | Cor | P | ||
| Monocyte | CD14 | −0.09 | 4.65E-03 | −0.09 | 2.88E-03 | 0.029 | 5.19E-01 | 0 | 9.98E-01 | −0.186 | 3.41E-05 | −0.192 | 1.24E-05 |
| Monocyte | CD86 | 0.207 | 4.60E-11 | 0.171 | 1.21E-08 | 0.233 | 1.82E-07 | 0.194 | 8.38E-06 | −0.105 | 1.99E-02 | −0.091 | 3.93E-02 |
| Monocyte | CD16 (FCGR3A) | 0.269 | 6.63E-18 | 0.25 | 3.49E-17 | 0.173 | 1.13E-04 | 0.136 | 1.83E-03 | −0.019 | 6.75E-01 | −0.009 | 8.32E-01 |
| TAM | CD68 | 0.179 | 1.26E-08 | 0.149 | 7.32E-07 | 0.271 | 1.06E-09 | 0.242 | 2.39E-08 | −0.027 | 5.50E-01 | −0.013 | 7.71E-01 |
| TAM | CCL2 | 0.034 | 2.88E-01 | 0.007 | 8.14E-01 | 0.336 | 2.01E-14 | 0.302 | 2.28E-12 | −0.101 | 2.64E-02 | −0.085 | 5.64E-02 |
| TAM | CCL5 | −0.049 | 1.19E-01 | −0.076 | 1.20E-02 | −0.043 | 3.39E-01 | −0.063 | 1.53E-01 | −0.201 | 7.57E-06 | −0.2 | 5.15E-06 |
| M1 macrophage | INOS (NOS2) | 0.118 | 2.00E-04 | 0.112 | 2.08E-04 | 0.53 | 6.31E-37 | 0.537 | 2.88E-40 | 0.222 | 6.94E-07 | 0.218 | 7.13E-07 |
| M1 macrophage | CXCL10 | 0.102 | 1.26E-03 | 0.065 | 3.03E-02 | −0.162 | 3.21E-04 | −0.179 | 4.02E-05 | −0.09 | 4.73E-02 | −0.067 | 1.31E-01 |
| M1 macrophage | TNF-α (TNF) | −0.002 | 9.54E-01 | −0.018 | 5.41E-01 | 0.143 | 1.52E-03 | 0.116 | 7.91E-03 | −0.167 | 2.12E-04 | −0.154 | 5.10E-04 |
| M2 macrophage | CD206 (MRC1) | 0.303 | 1.62E-22 | 0.249 | 5.55E-17 | 0.305 | 4.80E-12 | 0.231 | 9.51E-08 | −0.015 | 7.47E-01 | −0.009 | 8.39E-01 |
| M2 macrophage | CD163 | 0.265 | 2.06E-17 | 0.236 | 1.99E-15 | 0.279 | 3.09E-10 | 0.227 | 1.61E-07 | 0.164 | 2.71E-04 | 0.17 | 1.18E-04 |
| M2 macrophage | IL10 | 0.212 | 1.32E-11 | 0.176 | 4.26E-09 | 0.274 | 6.79E-10 | 0.222 | 3.04E-07 | 0.085 | 6.08E-02 | 0.084 | 5.92E-02 |
| Neutrophils | CD66b (CEACAM8) | 0.011 | 7.30E-01 | 0.026 | 3.95E-01 | 0.179 | 6.73E-05 | 0.182 | 2.78E-05 | −0.073 | 1.06E-01 | −0.068 | 1.27E-01 |
| Neutrophils | CD11b (ITGAM) | 0.185 | 3.89E-09 | 0.172 | 1.02E-08 | 0.393 | 1.24E-19 | 0.374 | 8.36E-19 | −0.087 | 5.48E-02 | −0.073 | 9.91E-02 |
| Neutrophils | CCR7 | 0.032 | 3.18E-01 | −0.005 | 8.76E-01 | 0.334 | 2.63E-14 | 0.286 | 2.56E-11 | −0.043 | 3.38E-01 | −0.031 | 4.80E-01 |
| Neutrophils | CD15 (FUT4) | 0.244 | 6.85E-15 | 0.202 | 1.38E-11 | 0.526 | 2.02E-36 | 0.533 | 1.27E-39 | 0.371 | 2.52E-17 | 0.373 | 3.23E-18 |
| Natural killer cell | KIR2DL1 | 0.018 | 5.66E-01 | 0.012 | 6.91E-01 | 0.103 | 2.19E-02 | 0.073 | 9.52E-02 | −0.069 | 1.29E-01 | −0.071 | 1.11E-01 |
| Natural killer cell | KIR2DL3 | 0.049 | 1.19E-01 | 0.041 | 1.74E-01 | 0.079 | 8.17E-02 | 0.062 | 1.56E-01 | −0.051 | 2.58E-01 | −0.044 | 3.25E-01 |
| Natural killer cell | KIR2DL4 | 0.031 | 3.28E-01 | 0.001 | 9.75E-01 | 0.071 | 1.14E-01 | 0.031 | 4.86E-01 | 0.079 | 8.12E-02 | 0.09 | 4.18E-02 |
| Natural killer cell | KIR3DL1 | 0.05 | 1.12E-01 | 0.042 | 1.60E-01 | 0.108 | 1.65E-02 | 0.083 | 5.88E-02 | 0.016 | 7.21E-01 | 0.017 | 7.10E-01 |
| Natural killer cell | KIR3DL2 | 0.028 | 3.74E-01 | 0.012 | 6.80E-01 | 0.2 | 7.96E-06 | 0.178 | 4.22E-05 | −0.037 | 4.09E-01 | −0.022 | 6.22E-01 |
| Natural killer cell | KIR3DL3 | 0.004 | 9.06E-01 | 0 | 9.95E-01 | 0.053 | 2.41E-01 | 0.044 | 3.18E-01 | −0.096 | 3.42E-02 | −0.084 | 5.71E-02 |
| Natural killer cell | KIR2DS4 | 0.015 | 6.43E-01 | 0.002 | 9.35E-01 | 0.042 | 3.55E-01 | 0.013 | 7.59E-01 | −0.013 | 7.78E-01 | −0.016 | 7.25E-01 |
| Dendritic cell | HLA-DPB1 | −0.038 | 2.33E-01 | −0.044 | 1.41E-01 | 0.121 | 7.29E-03 | 0.093 | 3.38E-02 | −0.225 | 5.19E-07 | −0.211 | 1.50E-06 |
| Dendritic cell | HLA-DQB1 | −0.043 | 1.74E-01 | −0.056 | 6.51E-02 | 0.067 | 1.37E-01 | 0.059 | 1.76E-01 | −0.206 | 4.56E-06 | −0.201 | 4.88E-06 |
| Dendritic cell | HLA-DRA | 0.156 | 8.14E-07 | 0.12 | 7.09E-05 | 0.172 | 1.22E-04 | 0.142 | 1.16E-03 | −0.146 | 1.23E-03 | −0.129 | 3.47E-03 |
| Dendritic cell | HLA-DPA1 | 0.175 | 3.03E-08 | 0.134 | 8.84E-06 | 0.175 | 9.79E-05 | 0.151 | 5.55E-04 | −0.196 | 1.32E-05 | −0.173 | 8.73E-05 |
| Dendritic cell | BDCA-1 (CD1C) | 0.025 | 4.37E-01 | 0.006 | 8.52E-01 | 0.25 | 2.01E-08 | 0.223 | 2.59E-07 | −0.18 | 6.44E-05 | −0.162 | 2.40E-04 |
| Dendritic cell | BDCA-4 (NRP1) | 0.358 | 2.07E-31 | 0.334 | 4.34E-30 | 0.319 | 4.08E-13 | 0.29 | 1.40E-11 | 0.372 | 1.66E-17 | 0.371 | 4.84E-18 |
| Dendritic cell | CD11c (ITGAX) | 0.123 | 1.05E-04 | 0.088 | 3.61E-03 | 0.373 | 1.02E-17 | 0.306 | 9.03E-13 | −0.144 | 1.38E-03 | −0.127 | 3.99E-03 |
| Dendritic cell | NKp46 (NCR1) | 0.171 | 5.31E-08 | 0.161 | 8.41E-08 | 0.324 | 1.86E-13 | 0.312 | 2.76E-13 | 0.146 | 1.21E-03 | 0.146 | 9.71E-04 |
BRCA, breast invasive carcinoma; HNSC, head and neck squamous cell carcinoma; THCA, thyroid carcinoma.