Table 3.
Correlation analysis between PERK and related gene markers of adaptive immune cells in TIMER in BRCA, HNSC, and THCA.
| Description | Gene markers | BRCA (n = 1093) | HNSC (n = 520) | THCA (n = 501) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Purity | None | Purity | None | Purity | None | ||||||||
| Cor | p | Cor | P | Cor | p | Cor | p | Cor | p | Cor | P | ||
| CD8+ T cell | CD8A | 0.097 | 2.12E-03 | 0.057 | 5.81E-02 | 0.121 | 7.26E-03 | 0.089 | 4.13E-02 | 0.003 | 9.54E-01 | 0.015 | 7.33E-01 |
| CD8+ T cell | CD8B | 0.004 | 8.87E-01 | −0.028 | 3.58E-01 | 0.096 | 3.24E-02 | 0.077 | 8.01E-02 | −0.05 | 2.74E-01 | −0.049 | 2.74E-01 |
| T cell (general) | CD3D | −0.056 | 7.79E-02 | −0.079 | 8.65E-03 | 0.067 | 1.39E-01 | 0.043 | 3.25E-01 | −0.211 | 2.46E-06 | −0.199 | 5.84E-06 |
| T cell (general) | CD3E | 0.012 | 7.00E-01 | −0.024 | 4.23E-01 | 0.204 | 5.34E-06 | 0.167 | 1.27E-04 | −0.156 | 5.27E-04 | −0.146 | 9.66E-04 |
| T cell (general) | CD2 | 0.062 | 5.09E-02 | 0.021 | 4.96E-01 | 0.156 | 5.19E-04 | 0.128 | 3.32E-03 | −0.173 | 1.27E-04 | −0.158 | 3.36E-04 |
| B cell | CD19 | −0.062 | 5.22E-02 | −0.079 | 8.94E-03 | 0.348 | 1.83E-15 | 0.309 | 5.67E-13 | −0.104 | 2.20E-02 | −0.086 | 5.15E-02 |
| B cell | CD20 (MS4A1) | 0.065 | 4.06E-02 | 0.026 | 3.92E-01 | 0.383 | 1.19E-18 | 0.328 | 1.39E-14 | 0 | 9.91E-01 | 0.012 | 7.84E-01 |
| B cell | CD138 (SDC1) | −0.004 | 9.08E-01 | −0.007 | 8.10E-01 | 0.207 | 3.77E-06 | 0.201 | 3.85E-06 | 0.134 | 3.07E-03 | 0.135 | 2.27E-03 |
| B cell | CD23 (FCER2) | −0.096 | 2.39E-03 | −0.105 | 4.82E-04 | 0.345 | 3.59E-15 | 0.312 | 2.75E-13 | −0.132 | 3.55E-03 | −0.125 | 4.67E-03 |
| Th1 | T-bet (TBX21) | 0.021 | 5.01E-01 | −0.012 | 6.91E-01 | 0.136 | 2.49E-03 | 0.109 | 1.24E-02 | −0.072 | 1.14E-01 | −0.059 | 1.83E-01 |
| Th1 | STAT4 | 0.15 | 1.98E-06 | 0.104 | 5.59E-04 | 0.235 | 1.42E-07 | 0.205 | 2.37E-06 | −0.193 | 1.68E-05 | −0.186 | 2.43E-05 |
| Th1 | STAT1 | 0.354 | 1.14E-30 | 0.341 | 2.42E-31 | 0.063 | 1.63E-01 | 0.041 | 3.48E-01 | 0.144 | 1.44E-03 | 0.162 | 2.51E-04 |
| Th1 | IFN-γ (IFNG) | 0.083 | 8.53E-03 | 0.047 | 1.22E-01 | −0.033 | 4.70E-01 | −0.05 | 2.55E-01 | −0.115 | 1.13E-02 | −0.105 | 1.76E-02 |
| Th1 | TNF-α (TNF) | −0.002 | 9.54E-01 | −0.018 | 5.41E-01 | 0.143 | 1.52E-03 | 0.116 | 7.91E-03 | −0.167 | 2.12E-04 | −0.154 | 5.10E-04 |
| Th2 | GATA3 | 0.159 | 4.97E-07 | 0.181 | 1.50E-09 | 0.073 | 1.08E-01 | 0.051 | 2.43E-01 | 0.062 | 1.72E-01 | 0.08 | 7.27E-02 |
| Th2 | STAT6 | 0.207 | 4.76E-11 | 0.21 | 1.99E-12 | 0.414 | 8.53E-22 | 0.427 | 0.00E+00 | 0.235 | 1.54E-07 | 0.242 | 3.14E-08 |
| Th2 | STAT5A | 0.022 | 4.91E-01 | 0.025 | 4.08E-01 | 0.298 | 1.60E-11 | 0.29 | 1.49E-11 | 0.03 | 5.03E-01 | 0.034 | 4.40E-01 |
| Th2 | IL13 | −0.022 | 4.98E-01 | −0.036 | 2.31E-01 | 0.068 | 1.30E-01 | 0.054 | 2.16E-01 | −0.128 | 4.75E-03 | −0.124 | 5.11E-03 |
| Tfh | BCL6 | 0.208 | 3.72E-11 | 0.201 | 1.82E-11 | 0.68 | 6.19E-68 | 0.686 | 0.00E+00 | 0.213 | 1.94E-06 | 0.215 | 9.49E-07 |
| Tfh | IL21 | 0.129 | 4.53E-05 | 0.115 | 1.31E-04 | 0.209 | 3.02E-06 | 0.213 | 8.57E-07 | 0.005 | 9.19E-01 | 0.013 | 7.78E-01 |
| Tfh | CD278 (ICOS) | 0.126 | 6.88E-05 | 0.084 | 5.14E-03 | 0.197 | 1.12E-05 | 0.165 | 1.57E-04 | −0.083 | 6.58E-02 | −0.066 | 1.37E-01 |
| Tfh | CXCL13 | −0.035 | 2.64E-01 | −0.058 | 5.36E-02 | 0.256 | 8.63E-09 | 0.205 | 2.48E-06 | −0.067 | 1.40E-01 | −0.063 | 1.59E-01 |
| Th17 | STAT3 | 0.437 | 1.45E-47 | 0.454 | 6.26E-57 | 0.567 | 3.19E-43 | 0.572 | 0.00E+00 | 0.539 | 4.19E-38 | 0.542 | 2.97E-40 |
| Th17 | IL17A | 0.02 | 5.24E-01 | 0.024 | 4.34E-01 | 0.191 | 1.99E-05 | 0.178 | 4.43E-05 | −0.074 | 1.04E-01 | −0.066 | 1.38E-01 |
| Treg | FOXP3 | 0.082 | 9.84E-03 | 0.044 | 1.47E-01 | 0.37 | 2.11E-17 | 0.331 | 1.00E-14 | −0.181 | 5.69E-05 | −0.159 | 3.14E-04 |
| Treg | CCR8 | 0.275 | 9.54E-19 | 0.242 | 3.91E-16 | 0.492 | 2.13E-31 | 0.453 | 9.81E-28 | 0.06 | 1.89E-01 | 0.073 | 9.89E-02 |
| Treg | STAT5B | 0.237 | 3.84E-14 | 0.246 | 1.20E-16 | 0.541 | 8.22E-39 | 0.536 | 3.54E-40 | 0.523 | 1.18E-35 | 0.532 | 1.47E-38 |
| Treg | TGFβ (TGFB1) | 0.014 | 6.59E-01 | 0.01 | 7.36E-01 | 0.102 | 2.40E-02 | 0.069 | 1.14E-01 | 0.055 | 2.27E-01 | 0.048 | 2.84E-01 |
| Treg | CD25 (IL2RA) | 0.167 | 1.13E-07 | 0.12 | 7.00E-05 | 0.369 | 2.80E-17 | 0.316 | 1.87E-13 | 0.019 | 6.71E-01 | 0.028 | 5.28E-01 |
| T-cell exhaustion | PD-1 (PDCD1) | −0.059 | 6.12E-02 | −0.083 | 6.06E-03 | 0.113 | 1.20E-02 | 0.086 | 4.86E-02 | −0.124 | 5.91E-03 | −0.106 | 1.68E-02 |
| T-cell exhaustion | CTLA4 | 0.012 | 7.04E-01 | −0.021 | 4.96E-01 | 0.121 | 7.39E-03 | 0.088 | 4.51E-02 | −0.188 | 2.94E-05 | −0.173 | 8.54E-05 |
| T-cell exhaustion | LAG3 | −0.089 | 4.88E-03 | −0.116 | 1.09E-04 | −0.013 | 7.81E-01 | −0.033 | 4.47E-01 | −0.208 | 3.49E-06 | −0.203 | 3.75E-06 |
| T-cell exhaustion | TIM-3 (HAVCR2) | 0.224 | 8.53E-13 | 0.194 | 7.79E-11 | 0.215 | 1.57E-06 | 0.179 | 4.13E-05 | −0.071 | 1.16E-01 | −0.059 | 1.84E-01 |
| T-cell exhaustion | GZMB | −0.044 | 1.70E-01 | −0.065 | 3.08E-02 | −0.019 | 6.74E-01 | −0.045 | 3.08E-01 | −0.193 | 1.81E-05 | −0.187 | 2.08E-05 |