. 2020 Dec 10;137(17):2337–2346. doi: 10.1182/blood.2020009499

Table 2.

T-cell–activation parameters distinguishing patients with HLH and sepsis

Activation marker	Sensitivity	Specificity	PPV	NPV	LR
CD8⁺ CD38⁺ >22%	0.93 (0.81-0.97)	0.89 (0.68-98.1)	0.95 (0.84-0.99)	0.85 (0.64-0.95)	8.8
CD8⁺ HLA-DR⁺ >27%	0.86 (0.66-0.95)	0.88 (0.56-0.99)	0.95 (0.76-1.0)	0.72 (0.43-0.90)	7.7
CD8⁺ CD38⁺ HLA-DR⁺ >7%	1.0 (0.85-1)	0.89 (0.56-0.99)	0.96 (0.79-1)	1 (0.67-1)	9
CD4⁺ CD38⁺ >17.4%	0.63 (0.42-0.80)	0.66 (0.35-0.88)	0.82 (0.59-0.94)	0.43 (0.21-0.67)	1.9
CD4⁺ HLA-DR⁺ >2%	0.95 (0.76-1.0)	0.88 (0.56-0.99)	0.95 (0.76-1)	0.89 (0.56-0.99)	8.5
CD4⁺ CD38⁺ HLA-DR⁺ >1.2%	0.85 (0.64-0.95)	0.89 (0.56-0.99)	0.94 (0.74-0.99)	0.73 (0.43-0.90)	7.6

Bold represents the parameter with the highest LR.