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. 2021 Apr 15;12:645264. doi: 10.3389/fphar.2021.645264

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Copyright © 2021 Boorgula, Jakkula, Gumbo, Jung and Srivastava.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MIC distribution and concentration-response of rifamycins against MIC. (A). MIC distribution of 20 MAC clinical isolates against the three rifamycins. (B). Bacteria was exposed to different static concentrations of the drugs for seven days. The solid line is for model fit, and symbols represent the data point. The kill below stasis [day 0 or inoculum] with rifampin was 2.68 (95% Confidence Interval (CI): 1.13 to 4.24) log₁₀ CFU/mL, for rifapentine was 3.03 (95% CI: 2.89 to 3.17) log₁₀ CFU/mL, and for rifabutin was 3.59 (95% CI: 2.22 to 4.96) log₁₀ CFU/mL, respectively.