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. 2021 Apr 15;12:645264. doi: 10.3389/fphar.2021.645264

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Copyright © 2021 Boorgula, Jakkula, Gumbo, Jung and Srivastava.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Efficacy of rifampin and resistance emergence in the HFS-MAC. (A-C). All three rifampin exposures showed virtually identical kill of MAC for the first 4-days, then failed due to emergence of rifampin resistance in the HFS-MAC. The lowest rifampin exposure AUC/MIC = 193 while failed to control the emergence of drug resistance, had lowest drug-resistant subpopulation by the end of the study. (D). Inhibitory Sigmoid E_max model to show the relationship between the rifampin exposure and bacterial burden. On day 14 [with highest r ² = 0.999 and lowest Akaike Information Criteria score (Akaike, 1974) = 0.009], EC₅₀ was calculated as AUC/MIC of 197.3.