TABLE 6.
Comparison of kill slopes and bacterial burden in HFS-MAC treated with different rifamycins.
| Drug exposure (fAUC/MIC) | Kill between day 0–4 (log10 CFU/mL) | Kill slope for day 0–4 (log10 CFU/ml/day) | Difference with non-treated control (log10 CFU/mL) | Difference between total and drug-resistant population (log10 CFU/mL) |
|---|---|---|---|---|
| Rifampin 192.97 | 1.07 | −0.27 | 1.76 | 1.45 |
| Rifampin 633.33 | 1.00 | −0.25 | 0.80 | 0.71 |
| Rifampin 1328 | 1.19 | −0.30 | 1.89 | 0.00 |
| Rifapentine 46.1 | 1.10 | −0.27 | 1.87 | 0.12 |
| Rifapentine 73.87 | 0.93 | −0.23 | 1.13 | 0.47 |
| Rifapentine 435 | 1.12 | −0.28 | 1.85 | 0.35 |
| Rifabutin 417.33 | 1.06 | −0.27 | 1.73 | −0.23 a |
| Rifabutin 897 | 0.90 | −0.23 | 1.05 | 0.72 |
| Rifabutin 1606.33 | 0.81 | −0.20 | 1.18 | 0.45 |
a
Negative value show that the drug resistant population replaced entire drug susceptible population.