Table 2.

Univariate and multivariable analyses for covariables associated with progression free survival.

Characteristics	Category	Univariate analysis HR (95 %CI)	p	Multivariate analysis HR (95 %CI)	p
Age	≤65 vs >65 years	0.71 (0.43-1.19)	0.194
Sex	Male vs female	0.88 (0.53-1.46)	0.630
Smoking history	Yes vs no	1.43 (0.88-2.35)	0.153
Treatment line	Second line vs posterior line	1.15 (0.36-3.68)	0.814
Brain	Yes vs No	1.40 (1.05-1.87)	0.024	0.74 (0.39-1.41)	0.361
PD-L1 expression	1-49% vs 0	0.46 (0.23-0.92)	0.027	0.47 (0.22-1.03)	0.058
	≥50% vs 0	0.33 (0.16-0.70)	0.004	0.46 (0.21-1.02)	0.057
	Unknown vs 0	0.71 (0.32-1.61)	0.414	0.60 (0.25-1.42)	0.246
EGFR mutation	21L858R vs 19del	0.60 (0.33-1.09)	0.092	0.41 (0.19-0.90)	0.024
	T790M vs 19del	0.83 (0.33-2.11)	0.691	0.47 (0.17-1.26)	0.133
	Others vs 19del	0.47 (0.19-1.14)	0.095	0.38 (0.14-1.04)	0.059
Therapy	I+C vs IM	0.22 (0.11-0.45)	<0.001	0.16 (0.07-0.37)	<0.001
	I+A vs IM	0.41 (0.23-0.73)	0.002	0.31 (0.16-0.57)	<0.001
	I+C vs I+A	0.53 (0.27-1.06)	0.071	0.55 (0.25-1.19)	0.126