Table 3.

Univariate and multivariable analyses for covariables associated with overall survival.

Characteristics	Category	Univariate analysis HR (95 %CI)	p	Multivariate analysis HR (95 %CI)	p
Age	≤65 vs >65 years	0.65 (0.32-1.22)	0.168
Sex	Male vs female	0.67 (0.33-1.35)	0.264
Smoking history	Yes vs No	1.50 (0.76-2.96)	0.242
Treatment line	Second line vs posterior line	0.47 (0.14-1.54)	0.211
Brain	No vs Yes	0.51 (0.24-1.09)	0.082	1.31 (0.88-1.93)	0.180
PD-L1 expression	1-49% vs 0	0.64 (0.30-1.59)	0.339	0.94 (0.35-2.48)	0.895
	≥50% vs 0	0.22 (0.07-0.67)	0.007	0.30 (0.10-0.94)	0.039
	Unknown vs 0	1.74 (0.67-4.55)	0.257	2.27 (0.84-6.15)	0.107
EGFR mutation	21L858R vs 19del	0.79 (0.36-1.72)	0.557
	T790M vs 19del	0.83 (0.32-4.32)	0.802
	Others vs 19del	0.58 (0.18-1.86)	0.361
Therapy	I+C vs IM	0.34 (0.13-0.85)	0.021	0.35 (0.13-0.93)	0.035
	I+A vs IM	0.41 (0.19-0.87)	0.020	0.40 (0.19-0.86)	0.019
	I+C vs I+A	0.82 (0.30-2.23)	0.700	0.88 (0.31-2.46)	0.807