Figure 3.

DEGs and intercellular signaling in tubules of IgAN and control subjects. (A) Representative DEGs in proximal tubule cells, distal tubule cells, loop of Henle cells, principal cells, and intercalated cells by comparing the transcriptional profile of IgAN and control subjects. (B) GO enrichment analysis displayed that upregulated DEGs in proximal tubule cells were enriched in some biological processes, KEGG analysis showed these genes in proximal tubule cells were mainly involved in the pathways, such as TNF signaling, IL-17 signaling, and NOD-like receptor signaling pathway. (C–F) GO and KEGG enrichment analysis of DEGs in distal tubule cells, loop of Henle cells, principal cells, and intercalated cells respectively comparing IgAN to control subjects. Abbreviations were as follows: pct.exp, percentage of cells expressing gene; count, number of genes annotated to GO terms or KEGG pathway.