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. 2021 Apr 16;12:646307. doi: 10.3389/fphar.2021.646307

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Copyright © 2021 Xu, Ge, Hu, Yu, Guo and Miao.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sevoflurane postconditioning decreases hepatic I/R injury. Mice (n = 6/group) were subjected to ischemia, then post-treatment with inhalation of 2% Sevo for 2 h immediately at the onset of reperfusion. (A) Liver enzyme assays were performed in the three groups: sham, HIRI and HIRI + Sevo groups. (A): Serum ALT levels; (B): Serum AST levels; (C): Serum LDH levels). (D, E) Liver damage induced by I/R was visualized using HE staining and was graded using the Suzuki score. The inflammatory cell infiltration is indicated with black arrow and necrotic areas is indicated with curve. (F, G) The expression of cleaved-caspase-3 was measured by IHC. (H) The apoptosis was determined by TUNEL staining assay. (I) The expression of cleaved caspase-3 was detected by Western Blot. All data were measurement data which were expressed as mean ± standard deviation and analyzed by one-way analysis of variance. **p < 0.01 vs. Sham group; ^## p < 0.01 vs. HIRI group.