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. 2021 Apr 16;11:656628. doi: 10.3389/fonc.2021.656628

Figure 4.

Figure 4

miR-21-5p expression was positively correlated with FOSL1 in HNSCC. (A) The representative images of miR-21-5p ISH staining and FOSL1 IHC staining. Scale bar, 300μm (B) FOSL1 expression was positively correlated with miR-21-5p expression. (C) The expression of FOSL1 was increased in HNSCC as comparted to the normal tissue. ***P < 0.001 by Student’s t-test (D) The expression of FOSL1 was increased in T3,4 stage HNSCC patient as comparted to those with T1,2 stage. *P < 0.05 by Student’s t-test (E) The expression of FOSL1 was increased in HNSCC patient with lymph node metastasis as comparted to those without lymph node metastasis. *P < 0.05 by Student’s t-test. (F) HNSCC patient with high FOSL1 expression levels indicated a poor overall survival. (G) HNSCC patient with high miR-21-5p expression levels indicated a poor overall survival. (H) HNSCC patient with high FOSL1 and miR-21-5p expression levels indicated a poorest overall survival.