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Arrows indicate the time from injection (or oral administration in the case of oral semaglutide) to peak plasma concentrations (Cmax) for GLP-1 RAs (Tmax). For references, please see [20]. Peak plasma concentrations may determine the time when nausea and vomiting are observed with GLP-1 RA treatment. The extremely slow absorption of once-weekly exenatide does not allow identification of a peak.
