Figure 7.
Results of cardiovascular outcome studies comparing GLP-1 RAs with placebo on a background of standard of care. (A) Reduction in major adverse cardiovascular events (MACE: time to first event) in published individual clinical trials. (B) Results of a published meta-analysis [108] analyzing various cardiovascular endpoints across all of the clinical trials shown in panel A. MACE (a combination of either cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) was the primary endpoint in all studies. Meta-analysis results are supplemented with I2 and related p values indicating the heterogeneity of the analysis of individual endpoints (column of panels to the far right) as reported in [108].