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. 2021 Apr 16;12:640297. doi: 10.3389/fphar.2021.640297

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Copyright © 2021 Zhang, Jiang, Wang, Lin, Zhang, Zhang, Zhu, Ng, Qu, Sze and Yung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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AGNHW pre-treatment ameliorated neurological deficit and decreased infarct size in MCAO rat model (A) Illustration of experimental schedule. (B) The degree of neurological function was assessed by Zea long’s scoring on a five-point scale 24 h after reperfusion (n = 15) (C,D) Infarct size was measured by TTC staining 24 h after reperfusion (n = 5). Representative image (C) and statistical analysis of results of TTC staining (D). Data are means ± S.D. ^## p < 0.01, compared with the sham group; *p < 0.05 and **p < 0.01, compared with the vehicle group.