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. 2021 Apr 16;12:640297. doi: 10.3389/fphar.2021.640297

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Copyright © 2021 Zhang, Jiang, Wang, Lin, Zhang, Zhang, Zhu, Ng, Qu, Sze and Yung.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pre-treatment with AGNHW suppressed cell apoptosis and oxidative stress damage in MCAO model (A,B) Representative images (A) and results of statistical analysis (B) of TUNEL staining in the infarct area of the ischemic cortex in MCAO rats with or without pre-treatment with AGNHW (C, D) The status of oxidative stress was monitored by cerebral ROS (C) and MDA (D) levels, analyzed by appropriate assay kits. N = 5 rats per group. Data are means ± S.D. ^## p < 0.01, compared with sham group; **p < 0.01, compared with vehicle group; ^a P < 0.05 and ^aa P<0.01, compared with AGNHW-L group; ^bb P<0.01, compared with AGNHW-M group.