Table 1.

Data-fitting for clausenidin release from clausenidin -loaded hydroxypropyl-β-cyclodextrin (Clu/HPβCD) in phosphate buffer solution PBS (pH 7.4).

Model	Slope	Intercept	R2	R2emp	RMSE	AIC	BIC	k
Zero-order	0.023633	11.390495	0.97081	0.98530	3.2027	12152.3	12162.6	–
First-order	0.000659	2.534267	0.08903	−3.96715	18.6755	16669.6	16679.9	–
Second-order	−24261.801930	62195462.267688	0.00002	−1387807544733.91990	62.6104	19768.9	19779.2	–
Korsmeyer-Peppas	0.897329	−2.691018	0.577100	−5311.72420	6.1839	13837.9	13848.2	0.068
Weibull	1.06384	−8.00729	0.64074	−7514.76132	4.5685	13062.2	13072.5	3002.777
Hixson-Crowell	0.000642	2.468205	0.70974	−3.98342	8.4591	14642.6	14658.0	0.001
Higuchi	0.500000	0.182904	0.65000	0.80623	11.6270	15455.5	15465.8	1.201
Michaelis-Menten	0.999219	7812500.062859	0.24961	−4.61895	62.6104	19770.9	19786.3	1.279E-07
Hill	1.343473	−9.313413	0.32203	0.89306	8.6374	14694.0	14704.3	11085.714
MTD	1659.972
DE	56.7716
No of timepoints	1281